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Pregnenolone is a steroid hormone produced by the adrenal glands, and synthesized directly from cholesterol. It, along with DHEA, sits atop what is known as the hormonal cascade. From DHEA and Pregnenolone, all other steroid hormones are created. Pregnenolone, which is made by the supporting tissues of the brain, can both stimulate and calm the brain. It activates the neuroreceptors, which take up glutamine, a substance which stimulates the brain. Pregnenolone seems to calm the brain by activating GABA receptors.
DHEA is referred to as the "mother" hormone because it's more prolific than any other hormone produced by the adrenal glands. This hormone, like the others, decreases with age. A peak level occurs at ages 25-30.
Print out your faxable pre-consultation questionnaire How do you know you need hormone replacement therapy? Either your physician may order a blood serum test or you may choose to a saliva test yourself. Saliva hormone tests reflect the tissue concentration of your hormones. Blood and serum tests contain the total hormone, but your tissue are only bathed with the active or effective fraction as found in saliva. Active fraction measurements are superior to blood and urine measurements both in diagnosis and treatment. For more information on saliva testing, please click here.
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Dr.
Keri Topouzian
Anti-Aging Specialist
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